Influence of Protein Scaffold on Side-Chain Transfer Free Energies
نویسندگان
چکیده
منابع مشابه
A graphical model approach for predicting free energies of association for protein-protein interactions under backbone and side-chain flexibility
Biomolecular systems are governed by changes in free energy, and the ability to predict binding free energies provides both better understanding of biomolecular interactions and the ability to optimize them. We present the first graphical-model based approach, which we call GOBLIN (Graphical mOdel for BiomoLecular INteractions), for predicting binding free energies for all-atom models of protei...
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The Impact of Side-Chain Packing on Protein Docking Refinement
We study the impact of optimizing the side-chain positions in the interface region between two proteins during the process of binding. Mathematically, the problem is similar to side-chain prediction, which has been extensively explored in the process of protein structure prediction. The protein-protein docking application, however, has a number of characteristics that necessitate different algo...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2017
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.06.032